Police were called at approximately 14:45hrs on Monday, 26 April to reports of a man, believed aged 18, stabbed in Coolfin Road, E16.
Officers and London Ambulance Service attended but despite their best efforts he died at the scene.
A crime scene remains in place.
Enquiries into the circumstances continue.
There have been no arrests.
A section 60 has been authorised for the whole of Newham borough between 16:00hrs on Monday, 26 April and 07:00hrs on Tuesday, 27 April.
Anyone with information that could assist the investigation at this early stage is asked to contact police on 101 or tweet @MetCC and quote CAD 4050/26April. Alternatively, you can provide information anonymously via the independent charity Crimestoppers by calling 0800 555 111.
= Hard calls save lives. Are you close to someone on the fringes of knife crime? Do the right thing, please give information, 100 per cent anonymously, through the independent charity Crimestoppers.
No piece of information about knife crime is insignificant or too small. Any information you give to Crimestoppers can make a difference in reducing knife crime and the harm it causes to families.
Crimestoppers never ask your name and they cannot trace your call, your IP address or the device you use. Fill in their quick online form or call 0800 555 111. It could save a life.