Shortly after 12.30am on (Tuesday 20 April), police were called to a report of the rape of a woman in Wythenshawe.
Initial enquiries suggest a woman in her 20s was attacked in Kirkup Gardens.
A significant police presence remains in place as officers continue to search for evidence at the scene.
No arrests have been made, and officers are appealing to anyone with information to get in touch.
Chief Inspector Cara Charlesworth, of GMP’s City of Manchester South Division, said: “A truly horrendous incident took place last night and we are supporting the victim at this awful time with our specialist officers.
“At this stage this appears to have been a random and sickening attack and our officers are working tirelessly to identify those responsible.
“In the meantime, we have increased our police presence in the area, and the public should feel reassured that if they have any concerns they can approach our officers directly.
“I appreciate it was the middle of the night and there won’t have been many witnesses to this attack, but if anyone has any information then I implore you to get in touch as every bit of detail at this stage has the potential to be crucial.”
Anyone with information should contact police on 0161 8566063 quoting incident 73 of 20/04/2021. Details can also be passed anonymously to the independent charity Crimestoppers on 0800 555 111.