At approximately 5am on Thursday, 8 April, officers attended nine addresses in north west London to execute warrants.
The series of warrants followed an investigation by Specialist Crime officers in relation to Drekwon’s murder.
Five males, aged 18, 21, 21, 27 and 29 were all arrested for conspiracy to murder and were taken into custody at a north west London police station where they remain at this time.
Police were called to reports of a boy with stab injuries in Preston Road, Brent shortly after 11.30pm on Thursday, 18 February.
The victim was later identified as 16-year-old Drekwon Patterson who was from the Wembley area.
Drekwon was treated at the scene before being taken to the hospital. Despite the efforts of emergency services, he died shortly before 9am on Friday, 19 February.
Police enquiries continue to identify the remaining suspects and officers are asking anyone with further information to contact the police.
Detective Sergeant David Pearce, of the Met’s Specialist Crime Command said: “The success of today’s operation was the result of a collaboration between a variety of specialist Met units supported by local officers to detain five violent men.
“We are committed to ensuing that those responsible for this murder are identified, apprehended and placed before the courts.
“We are pursuing additional lines of enquiry and urge anyone with any information, however small, to get in touch.”
Anyone with any information is asked to call the incident room on 020 8721 4622 or call police on 101 quoting CAD 8167/18Feb.
Alternatively, information can be given anonymously to Crimestoppers on 0800 555 111 or visit crimestopper_uk.org